Mildred Arlene (Brand) Anderson-Spence, 81 of Lexington passed away on Sunday March 15, 2020 at the Plum Creek Care Center in Lexington, where she had been on hospice care. Arlene was born on April 11, 1938 in Hendley NE to Frank and Ruth (Harold) Brand. She was the fourth child of eleven children ,so she did alot of babysitting her younger siblings. She attended school in Hendley and Beaver City NE. She was united in marriage to John Dorrance Anderson on November 4, 1954. To this union four children were born: Judy, Nyla, John and Jim. The couple lived in Edison and moved to Lexington in 1965. John preceded her in death on August 9, 1988. In October 1993 she was united in marriage to Lonnie Spence, the couple divorced in 1995. Arlene was a member of the Trinity Lutheran Church in Lexington. She enjoyed doing Sudoku puzzles, was an avid reader and enjoyed taking care of her lawn. She enjoyed watching the kids sports when she was younger, then later enjoyed spending time with family. Survivors include: Two daughters, Judy (Ed) Anderson of Lincoln NE and Nyla Anderson of Grand Island NE.; Two sons, John Anderson of Lexington NE and Jim (Lisa) Anderson of Grand Island NE. Eight grandchildren: Tim (Kelly) Keesecker of Manhattan KS ,Aaron (Katie) Keesecker of Moline IL, Kelly (Shawn) Carmona of Dodge City KS, Jeremy (Melissa) Schroeder of Olathe KS, Michael Reynolds of Emporia KS, Megan Miller of Manhattan KS, Ryan (Jamye) Anderson of Grand Island NE, and Jackie (Jared) Ondracek of Wolbach NE. Fourteen great grandchildren: Ian, Carter and Jack Keesecker, David, Brooke and Lucas Keesecker, Roman and Paris Carmona, Evan and Dylan Schroeder, Wyatt and Shelby Anderson, and Jaxon and Jocelyn Ondracek. Three brothers: Frank Brand of San Mateo CA, Harold Brand of Norfolk VA and Richard (Jeanne) Brand of Edwardsville IL. Three sisters: Ruthie Little of Rocky Mount NC, Donna (Jack) Cusick of Littleton CO and Patty (Lacy) Hillyer of Peyton CO. as well as many nieces, nephews, extended family and friends. Arlene is preceded in death by her parents, husband, John, three brothers: Eldon Brand, Robert Brand and Kenneth Brand, and one sister, Merna (Shearer) Haught. Funeral services will be held on Saturday March 21, 2020 at 10:30 a.m. at Reynolds-Love Funeral Home in Lexington with Pastor Rob Kuefner, officiating. Visitation will be held one hour prior to the funeral service. Interment will be in the Greenwood Cemetery in Lexington. Memorials are suggested to American Cancer Society or the Lexington Public Library. Reynolds-Love Funeral Home in Lexington is honored to be assisting the family with arrangements. Please share online condolences with the family by visiting: reynoldslovefuneralhome.com